Cosa significa metronomica?
Cosa significa metronomica?
Cosa è la terapia Metronomica? È un approccio chemioterapico che prevede la somministrazione di farmaci a basso dosaggio, anche tutti i giorni. Il trattamento del paziente oncologico avviene attraverso una terapia orale, con una frequenza che va dal quotidiano alle due/tre volte alla settimana.
Is metronomic capecitabine effective in the treatment of TNBC?
- Conclusions: Maintenance therapy with metronomic capecitabine for one year following standard treatment significantly improved DFS in operable TNBC, which was safe and well tolerated. (SYSUCC-001, Clinical trial information: NCT01112826.
What are the renal dosing adjustments for capecitabine?
- Renal Dose Adjustments. -Mild renal impairment (CrCl 51 to 80 mL/min): No adjustment recommended. -Moderate renal impairment (CrCl 30 to 50 mL/min): Reduce the capecitabine starting dose to 75% (from 1250 mg/m mg/m2 orally 2 times a day)
When is a treatment delay indicated for capecitabine and docetaxel?
- At the beginning of a treatment cycle, if a treatment delay is indicated for either capecitabine or docetaxel, then administration of both agents should be delayed until the requirements for restarting both drugs are met.
Does capecitabine increase prothrombin time and INR after stabilization?
- -Postmarketing reports have shown clinically significant increases in prothrombin time (PT) and INR in patients who were stabilized on anticoagulants at the time capecitabine was introduced. -These events occurred within several days and up to several months after initiating therapy and, in a few cases, within one month after stopping therapy.
