Che significa Pleiotropiche?

Che significa Pleiotropiche?

pleiotropia Fenomeno per cui uno stesso gene manifesta più effetti fenotipici distinti. Quando un gene è pleiotropico si assume che esso determini caratteri fenotipici, almeno all'apparenza, non correlati tra di loro.

Che cosa si intende per Poliallelia?

poliallelia In genetica, l'esistenza di più di due alleli di uno stesso gene. Il numero complessivo di alleli diversi di un gene presenti in una popolazione può essere molto grande, anche se in un individuo diploide possono esserci solo due alleli di quel gene e in un individuo aploide solo uno.

What does pleiotropic mean in genetics?

• the production by a single gene of a complex of unrelated phenotypic effects. The effects may be a manifestation of a particular disorder, such as the cluster of symptoms in Marfan's syndrome; aortic aneurysm; dislocation of the optic lens; skeletal deformities; and arachnodactyly, any or all of which may be present. pleiotropic, adj.

What is the difference between pleiotropy and Developmental pleiotropy?

• 1 Pleiotropy is the expression of multiple traits by a single gene. 2 Gene pleiotropy is focused on the number of traits and biochemical factors impacted by a gene. 3 Developmental pleiotropy is focused on mutations and their influence on multiple traits.

Why is it difficult to detect Pleiotropic traits?

• It is often difficult to detect which traits may be the result of pleitoropy unless a mutation occurs in a gene. Because pleiotropic genes control multiple traits, a mutation in a pleiotropic gene will impact more than one trait.

Does pleiotropy influence outcome measurement?

• Collectively, these multifactorial effects raise the possibility of gene pleiotropy influencing the outcome measure, which could invalidate the Mendelian randomization (8). On the other hand, NMS may manifest as symptoms of aging-associated neurodegenerative disease through an antagonistic pleiotropy mechanism in the parental brains.