Cosa vuol dire MGUS?
Cosa vuol dire MGUS?
Gammopatia monoclonale di significato incerto (Monoclonal Gammopathy of Undetermined Significance, MGUS)
Che cosa è gammopatia monoclonale?
Le gammopatie monoclonali sono condizioni ematologiche caratterizzate dalla presenza, nel sangue dei pazienti, di un anticorpo monoclonale (chiamato anche componente monoclonale), prodotto da particolari cellule del sistema immunitario dette plasmacellule.
What is monoclonal IgG Kappa?
- The most common monoclonal protein in myeloma is the IgG type. This means that the immunoglobulin is comprised of two IgG heavy chains and two light chains, either two kappa or two lambda. When the abnormal M protein is identified in myeloma, it is most often an IgG kappa type.
What causes MGUS disease?
- The precise cause of MGUS isn't known. Genetic changes and environmental triggers appear to play a role. Factors that increase your risk of developing MGUS include: Age. The average age at diagnosis is 70 years. Race. Africans and African Americans are more likely to experience MGUS than are white people. Sex. MGUS is more common in men.
How serious is MGUS?
- You may have a higher risk of MGUS if other people in your family have the condition. Each year about 1% of people with MGUS go on to develop certain types of blood cancers or other serious diseases such as: Other complications associated with MGUS include bone fractures, blood clots and kidney problems.
Does MGUS ever go away?
- However, in a small number of people, monoclonal gammopathy of undetermined significance may progress to some more serious disorders like multiple myeloma. While MGUS does not go away, fortunately it does not require treatment in most cases. Watchful waiting is advised, and certain medications can help in some cases of MGUS.
