What is indole used for?

What is indole used for?

Indole-3-carbinol is used for prevention of breast cancer, colon cancer, and other types of cancer. The National Institutes of Health (NIH) has reviewed indole-3-carbinol as a possible cancer preventive agent and is now sponsoring clinical research for breast cancer prevention.

What does indole do for bacteria?

Indole has recently been implicated as an important small molecule signal utilized by many bacteria to coordinate various forms of behavior. Indole plays a role in numerous bacterial processes, including: biofilm formation and maintenance, virulence factor production, antibiotic resistance and persister cell formation.

What is called indole?

indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter.

What does indole test determine?

The indole test is a qualitative procedure for determining the ability of bacteria to produce indole by deamination of tryptophan. Using Kovacs method, indole combines, in the presence of a tryptophan rich medium, with p-Dimethylaminobenzaldehyde at an acid pH in alcohol to produce a red-violet compound.

What foods are high in indoles?

Indoles are found in broccoli, bok choy, cabbage, kale, Brussel sprouts, and turnips (also known as "cruciferous" vegetables). They contain sulfur and activate agents that destroy cancer-causing chemicals.

Which drugs indole alkaloids?

Important indole alkaloids which have been isolated from plants include the antihypertensive drug, reserpine from Rauvolfia serpentina (Sagi et al., 2016) and the powerful antitumor drugs, vinblastine and vincristine from Catharanthus roseus (El-Sayed and Verpoorte, 2007).

How do you make indole?

Indole can still be synthesized, however, using the Fischer indole synthesis by reacting phenylhydrazine with pyruvic acid followed by decarboxylation of the formed indole-2-carboxylic acid. This has also been accomplished in a one-pot synthesis using microwave irradiation.

Where is indole created?

Indole is generated by reductive deamination from tryptophan via the intermediate molecule indolepyruvic acid. Tryptophanase catalyzes the deamination reaction, during which the amine (-NH2) group of the tryptophan molecule is removed.

Why is indole test performed?

The indole test is a biochemical test performed on bacterial species to determine the ability of the organism to convert tryptophan into indole. This division is performed by a chain of a number of different intracellular enzymes, a system generally referred to as "tryptophanase."

Where can I get indole?

Indole-3-carbinol is formed from a substance called glucobrassicin found in vegetables such as broccoli, Brussels sprouts, cabbage, collards, cauliflower, kale, mustard greens, turnips, and rutabagas. Indole-3-carbinol is formed when these vegetables are cut, chewed or cooked. It can also be produced in the laboratory.

What are the uses of indole?

• Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.

Are indoles phytochemicals?

• Indoles are a class of phytochemicals associated with cancer prevention. You should consult your physician before altering your diet to increase your indole intake.

What is indole production test?

• Indole test. The indole test is a biochemical test performed on bacterial species to determine the ability of the organism to split indole from the amino acid tryptophan . This division is performed by a chain of a number of different intracellular enzymes, a system generally referred to as "tryptophanase.".

What is an indole ring?

• Indole is an aromatic heterocyclic organic compound with formula C8H7N. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indole is widely distributed in the natural environment and can be produced by a variety of bacteria.