What is the life expectancy of someone with Marfan?

What is the life expectancy of someone with Marfan?

One in 10 patients may have a high risk of death with this syndrome due to heart problems. Despite the high risk for Marfan related cardiovascular problems, the average life expectancy of those with Marfan syndrome is nearly 70 years. The life expectancy in this syndrome has increased to greater than 25% since 1972.

What causes Marfan syndrome?

Marfan syndrome is caused by a mutation in a gene called FBN1. The mutation limits the body's ability to make proteins needed to build connective tissue. One in four people with Marfan syndrome develops the condition for unknown reasons. A person with Marfan syndrome has a 1 in 2 chance of passing it on to their child.

Does Marfan syndrome affect intelligence?

Some Marfan features – for example, aortic enlargement (expansion of the main blood vessel that carries blood away from the heart to the rest of the body) – can be life-threatening. The lungs, skin, and nervous system may also be affected. Marfan syndrome does not affect intelligence.

When do symptoms of Marfan syndrome appear?

People are born with Marfan syndrome but they may not notice any features until later in life and some of these features can appear at any age. Some people have many characteristics at birth or as young children. Other people develop aortic enlargement, as teens or even as adults.

What is the average age of death?

The United Nations estimate a global average life expectancy of 72.6 years for 2019 – the global average today is higher than in any country back in 1950. According to the UN estimates the country with the best health in 1950 was Norway with a life expectancy of 72.3 years.

Is Marfan syndrome painful?

Skeletal problems that develop as a result of Marfan syndrome can sometimes cause significant pain and discomfort. They may also affect your appearance, which some people find affects their confidence and self-esteem.

Can Marfan syndrome be cured?

While there is no cure for Marfan syndrome, treatment focuses on preventing the various complications of the disease. To accomplish this, you'll need to be checked regularly for signs that the damage caused by the disease is progressing.

Can you play sports with Marfan?

The general guidelines for people with Marfan syndrome are to avoid competitive and contact sports that would put added stress on the aorta, cause chest or eye trauma, or be potentially damaging to loose ligaments and joints.

Can you have kids if you have Marfan syndrome?

If one parent has the disorder, there is a 50% chance, with each pregnancy, for a child to also have Marfan syndrome. In addition, women with Marfan syndrome who become pregnant have significant risks for their health during pregnancy, due to the added stress that a pregnancy puts on the heart and aorta.

What is marfans?

Marfan syndrome is an inherited disorder that affects connective tissue — the fibers that support and anchor your organs and other structures in your body. Marfan syndrome most commonly affects the heart, eyes, blood vessels and skeleton.

What does the name Marfan mean?

• Marfan Syndrome. Definition. Marfan syndrome is an inherited disorder of the connective tissue that causes abnormalities of the patient's eyes, cardiovascular system, and musculoskeletal system. It is named for the French pediatrician, Antoine Marfan (1858–1942), who first described it in 1896.

What happens in Marfan syndrome, exactly?

• Marfan syndrome is a genetic disorder that affects the connective tissue.
• A child with Marfan syndrome may have problems with the bones and joints,heart and blood vessels,and eyes.
• A diagnosis of Marfan syndrome is based on signs,family history,and results of diagnostic tests.

What is the life expectancy for people with Marfan syndrome?

• The cardiac complications, particularly aortic dilatation, dissection and rupture and involvement of the aortic and mitral valves, lead to a greatly reduced life expectancy. This poor survival was demonstrated in a series of 257 patients with the Marfan syndrome. The average age at death for the 72 deceased patients was 32 years.