What is Moschcowitz syndrome?

What is Moschcowitz syndrome?

Moschcowitz syndrome or thrombotic thrombocytopenic purpura is a rare disorder with a poor prognosis. This syndrome is characterized by a microangiopathic hemolytic anemia with thrombocytopenia, neurologic symptoms and renal disease.

What are the symptoms of TTP?

Symptoms may include any of the following:

• Bleeding into the skin or mucus membranes.
• Confusion.
• Fatigue, weakness.
• Fever.
• Headache.
• Pale skin color or yellowish skin color.
• Shortness of breath.
• Fast heart rate (over 100 beats per minute)

Is TTP life threatening?

TTP is a rare disorder. It can be fatal or cause lasting damage, such as brain damage or a stroke, if it's not treated right away. TTP usually occurs suddenly and lasts for days or weeks, but it can continue for months.

What can cause TTP?

The exact cause of TTP is not known. However, the disease is associated with a deficiency of an enzyme involved in blood clotting called the von Willebrand factor cleaving protease (also called ADAMTS13).

What is papura?

Purpura is purple-colored spots and patches that occur on the skin, and in mucus membranes, including the lining of the mouth.

What is the most common cause of low platelet count?

One of the most common causes of low platelets is a condition called immune thrombocytopenia (ITP). You may hear it called by its old name, idiopathic thrombocytopenic purpura.

How long can you live with TTP?

In the authors' series of 126 patients, the estimated 10-year survival rate of patients without comorbid conditions was 82%, compared with a survival rate of 50% if comorbid conditions were present.

How do I treat TTP?

Treatment options for TTP refractory to PEX

1. Corticosteroids. Corticosteroids are used in the acute management of acquired TTP, and should be started upfront together with PEX. ...
2. Twice-daily PEX. ...
3. Rituximab. ...
4. Splenectomy. ...
5. Cyclosporine. ...
6. Cyclophosphamide and vincristine. ...
7. Bortezomib. ...
8. N-acetylcysteine.

Is TTP genetic?

Congenital TTP is caused by changes ( mutations ) in the ADAMTS13 gene and inheritance is autosomal recessive .

What should be avoided during TTP?

Do not drink or eat anything that contains quinine. Quinine can make TTP worse. Quinine is found in tonic water, flavored drinks, and some foods. Read all food and drink labels to check for quinine. Ask your healthcare provider for a full list of drinks and foods that contain quinine.