Quali esami sono alterati nel mieloma?

Quali esami sono alterati nel mieloma?

Gli esami di laboratorio più utili sono l'elettroforesi proteica e l'immunoelettroforesi di siero e urine. Con questi test si evidenzia e identifica il singolo anticorpo monoclonale prodotto in quantità anomala dalle cellule della maggior parte dei soggetti con mieloma multiplo.

Come viene diagnosticato il mieloma?

Il mieloma multiplo viene diagnosticato con esami del sangue e del midollo osseo, elettroforesi delle proteine nelle urine e indagini radiologiche.

What is the difference between IgG and IgA multiple myeloma?

• About 1 out of 2 people with multiple myeloma have M protein that contains IgG. IgA is the second most common type of heavy chain seen in M protein. About 1 out of 5 people with myeloma have the IgA type. Less often, M protein can be made from IgD or IgE.

Is persistent haematuria associated with IgA monoclonal gammopathy?

• In our patient, the history of persistent haematuria for 30 years before the identification of a monoclonal gammopathy, seems to suggest a different pathogenetic relationship between a polyclonal disorder and an IgA monoclonal gammopathy which terminated with clinically overt IgA myeloma.

How is Iga glomerulonephritis (Iga-GN) diagnosed?

• A definite diagnosis of IgA glomerulonephritis can only be made when a renal biopsy including immunofluorescence are available. Nevertheless the history of this patient suggests the presence of IgA-GN. At the time of the diagnosis of sympharyngitic nephritis was made (1964), IgA nephropathy had not yet been identified by Berger and Hinglais [ 5 ].

What is the prevalence of idiopathic immunoglobulin A (IgA) deficiency?

• IgA-GNF is a relatively common disorder, with a prevalence of 1–. The possibility that monoclonal gammopathy should have been present for 24 years is unlikely.