Cosa significa p63?

Cosa significa p63?

p63 è una proteina prodotta sia dalle cellule normali che dalle cellule tumorali. Dopo che è stato creato, p63 viene trattenuto in una parte della cella chiamata nucleo. I patologi usano un test chiamato immunoistochimica per vedere p63 all'interno delle celle.

Cosa significa e caderina positiva?

I ricercatori al centro del Cancro di Johns Hopkins Kimmel hanno scoperto che una proteina di aderenza delle cellule, E-cadherin, permette che le celle di cancro al seno sopravvivano a mentre attraversano through l'organismo e formano i nuovi tumori, un trattamento definito metastasi.

Cosa significa Immunoreattivita?

L'immunoreattività è una parola che i patologi usano per descrivere i risultati di un test chiamato immunoistochimica. Questo test viene eseguito per vedere se le cellule in un campione di tessuto producono una proteina di interesse.

Is p63 a diagnostic marker for non metaplastic invasive carcinoma?

• In stark contrast, only (0.6%) nonmetaplastic invasive carcinomas was positive for p63. All Phyllodes tumors and sarcomas were consistently negative for p63 expression. The sensitivity and specificity of p63 as a diagnostic marker for metaplastic carcinoma was 86.7% and 99.4%, respectively.

Where is p63 expressed in the body?

• p63, a member of the p53 gene family, is involved in cellular differentiation and is expressed in the nuclei of myoepithelial cells of normal breast ducts and lobules. Although p63 has been reported in metaplastic carcinomas of the breast, its expression pattern in breast carcinomas and sarcomas has …

What is the role of p63 In metaplastic carcinomas of the breast?

• Although p63 has been reported in metaplastic carcinomas of the breast, its expression pattern in breast carcinomas and sarcomas has not been fully characterized, and its potential diagnostic utility has not been defined.

Is p63 a useful diagnostic marker for spindle cell tumors of breast?

• The sensitivity and specificity of p63 as a diagnostic marker for metaplastic carcinoma was 86.7% and 99.4%, respectively. We propose the inclusion of p63 as part of the diagnostic workup of challenging spindle cell tumors of the breast as a highly specific marker for metaplastic carcinomas.