Quali sono i valori della calcitonina?
Quali sono i valori della calcitonina?
La calcitonina è un ormone polipeptidico secreto dalle cellule parafollicolari (cellule C), della tiroide....Generalità
| CALCEMIA | FOSFATEMIA |
|---|---|
| Valori normali: 10 mg/100 ml | Valori normali: 5 mg/100 ml |
| CALCITONINA - valori normali - | |
| Uomo: meno di 19 pg/ml | Donna: meno di 14 pg/ml |
How does calcitonin work in the body?
- Calcitonin works to control calcium and potassium levels. It does this by inhibiting the activity of the osteoclasts, the cells that break down bone. When the osteoclasts break down bone tissue, the calcium enters the bloodstream. By preventing the breakdown of bone, calcitonin lessens the amount of calcium in the blood.
What is the molecular structure of calcitonin?
- Structure. Calcitonin is a polypeptide hormone of 32 amino acids, with a molecular weight of 3454.93 daltons. Its structure comprises a single alpha helix. Alternative splicing of the gene coding for calcitonin produces a distantly related peptide of 37 amino acids, called calcitonin gene-related peptide (CGRP),...
What is the medical significance of Calcitonin assay?
- Medical Significance. Calcitonin assay is used in identifying patients with nodular thyroid diseases. It is helpful in making an early diagnosis of medullary carcinoma of thyroid. A malignancy of the parafollicular cells, i.e. Medullary thyroid cancer, typically produces an elevated serum calcitonin level.
How does calcitonin affect osteoclastic activity?
- Osteoblasts do not have calcitonin receptors and are therefore not directly affected by calcitonin levels. However, since bone resorption and bone formation are coupled processes, eventually calcitonin's inhibition of osteoclastic activity leads to increased osteoblastic activity (as an indirect effect).
